The aims and objectives of the D[4]/ PHENODENT project are to create a collaborative interactive biomedical database D[4] (Diagnosing Dental Defects Database) linked to a dynamic web site PHENODENT allowing standardisation of data collection and therefore assisting in oro-dental phenotyping.
This tool will permit integration of these data within the medical and genetic general context enhancing multidisciplinary patient management approaches. It will facilitate understanding of dental and oral biology and associated disorders and diseases implementing science based evidence diagnosis and therapeutic options. These data might be used in public health as markers of gene/environment relationships in the case of acquired dental defects. D[4]/ PHENODENT will stimulate patient recruitment and install a basis for molecular analysis and anatomo-pathological investigations. It will allow the creation of larger cohorts of patients, presenting with these rare oro-dental defects, that could be involved in future research projects like - Oro-dental phenotypes in syndromes - Identification of mutations in known genes involved in dental development and diseases - Phenotype/genotype correlation - Population genetics – New gene identification - Gene expression during odontogenesis - Mouse/Human correlations. Standardisation will facilitate sharing of data and materials among investigators.
This tool will offer links to other genetic databases like Orphanet, OMIM, LDDB. It will be accessible via HC Forum ®, a secure web based platform dedicated to genetics.
PHENODENT will constitute a link between participating clinical diagnosis centres and research laboratories thus representing a powerful tool for national (French INSERM GIS rare diseases, Odontogenetics network) and international (European COST B23 Orofacial development and regeneration) networks.
This work is funded partially via INSERM " Reseau de Recherche Clinique et Reseaux de Recherche en Sante des populations 2003 ".
The project
/ PHENODENT Project